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Evolving an anti-toxin antibody

Article Abstract:

The new antibody with cross-reactivity for two epitopes might have better therapeutic or diagnostic potential than its parent monoclonal antibodies (mAbs). The molecular basis of the broadened specificity is determined by using structural analysis.

Author: Presta, Leonard

Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2007

Analysis, Molecular structure, Monoclonal antibodies, Antigenic determinants, Structure

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Bridging the knowledge gaps in vaccine design

Article Abstract:

The vaccines against the pathogens portraying various antigens and requiring T-cell immunity call for better understanding of the molecular nature of the epitopes and the mechanisms of the T-cell and mucosal immunity.

Author: Rappuoli, Rino

Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2007

Physiological aspects, Vaccines, T cells

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Subjects list: Research

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